Efficacy of adjunctive cerebellar HD-tDCS on craving in Alcohol Dependence Syndrome.
- Conditions
- Health Condition 1: F102- Alcohol dependence
- Registration Number
- CTRI/2023/03/051030
- Lead Sponsor
- Central Institute of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Subjects diagnosed with mental and behavioral disorders due to use of alcohol, dependent syndrome,currently using the substance (F10.24) as per International Classification of disease 10th (ICD-10, DCR) Diagnostic Criteria for Research.
2.Age between 18-50 years
3.Ready to give informed consent
4.Right-handed
5.Educated up to class VIII or above
6.Clinical institute withdrawal assessment for alcohol revised (CIWA-AR) protocol score less than 10.
1.Subject having alcohol related complicated withdrawal.
2.Any comorbid substance use disorder except nicotine and caffeine.
3.Participants with hepatic derangements or impaired liver function test (LFT).
4.Patients with metal in cranium, pacemaker, history of significant traumatic brain injury; history of epilepsy and cerebrovascular accident(CVA); skin problems such as dermatitis, psoriasis, or eczema over the scalp.
5.Participants having any contraindications for undergoing HDtDCS and fMRI study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in scores of cravings as rated by Alcohol Craving Questionnaire (ACQ) and Obsessive-Compulsive Drinking Scale (OCDS) after 2 and 4 weeks of HDtDCS treatment.Timepoint: Reduction in scores of cravings as rated by Alcohol Craving Questionnaire (ACQ) and Obsessive-Compulsive Drinking Scale (OCDS) after 2 and 4 weeks of HDtDCS treatment.
- Secondary Outcome Measures
Name Time Method Changes in cue based BOLD activation as measured by fMRI after 2 and 4 weeks of HDtDCS treatment.Timepoint: Changes in cue based BOLD activation as measured by fMRI after 2 and 4 weeks of HDtDCS treatment.