Influence of IVIG on nerve excitability in multifocal motor neuropathy (MMN) - IVIG and excitability in MM

niversitair Medisch Centrum Utrecht0 个研究点目标入组 45 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

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•1. Diagnosis of MMN according to internationally accepted criteria of the European Federation of Neurological Societies and Peripheral Nerve Society (EFNS/PNS criteria).
•2. One median nerve (left or right) with any of the following findings in the forearm segment:
•(a) conduction block, defined as segmental reduction of compound muscle action potential (CMAP) area of at least 30% or signs of demyelination: conduction velocity decrease up to 38 m/s or less and/or DML 5.3 ms or more and/or increased CMAP duration prolongation in the forearm of at least 30%;
•(b) motor axon loss defined as decreased CMAP amplitude of 3 mV or less;
•(c) normal conduction studies.
•3. Treatment with IVIG.
•4. Age range will be considered between 18 and 99 years.

•1. Other causes for neuropathy than MMN, including carpal tunnel syndrome (CTS).
•2. Use of medication affecting peripheral nerve ion-channel currents.

发起方

niversitair Medisch Centrum Utrecht