Wean Early With HFNCO vs NPPV in Patients With AHRF

Not Applicable

• Conditions: Patients With Acute Hypoxemic Respiratory Failure
• Interventions: Device: Noninvasive Positive Pressure Ventilation; Device: High-Flow Nasal Cannula Oxygenation; Device: Conventional weaning

• Registration Number: NCT03171935
• Lead Sponsor: Beijing Chao Yang Hospital

Brief Summary

The main purpose of the present study is to verify whether, as compared with conventional weaning, early weaning with high-flow nasal cannula oxygenation or noninvasive positive pressure ventilation may more effective in shortening the duration of invasive ventilation, hence reducing the rates of complications and mortality in patients with acute hypoxemic respiratory failure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-05-29
• Study First Submitted QC: 2017-05-29
• Study First Posted: 2017-05-31
• Study Start: 2017-06-01
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-30
• Last Update Posted: 2021-07-02
• Primary Completion: 2021-12-31
• Study Completion: 2022-03-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 270

Inclusion Criteria

1. Orotracheal intubation；
2. PaO2 <60mmHg（venturi mask，FiO2=0.5），and PaCO2 ≤45mmHg；
3. Meeting criteria for weaning readiness；
4. Spontaneous breathing trial failure.

Exclusion Criteria

1. Age<18；
2. Duration of invasive ventilation <48h；
3. Tracheotomy；
4. Percentage of cuff leak volume in tidal volume<15.5%；
5. Unable to spontaneously clear secretions from their airway；
6. Recent oral，nasal，facial or cranial trauma or surgery；
7. Recent gastric or esophageal surgery；
8. Active upper gastro-intestinal bleeding；
9. Severe abdominal distension；
10. Lack of co-operation；
11. Chronic respiratory disease such as chronic obstructive pulmonary disease, asthma, interstitial lung disease and neuromuscular disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Noninvasive Positive Pressure Ventilation	Noninvasive Positive Pressure Ventilation	-
High-Flow Nasal Cannula Oxygenation	High-Flow Nasal Cannula Oxygenation	-
Conventional Weaning	Conventional weaning	-

Primary Outcome Measures

Name	Time	Method
Duration of invasive mechanical ventilation	2.5 years

Trial Locations

Locations (1)

Beijing Institute of Respiratory Medicine, Department of respiratory and critical care medicine, Beijing Chao-Yang Hospital Jingxi Campus, Capital Medical University; 🇨🇳 Beijing, China