Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

University Hospital, Clermont-Ferrand1 site in 1 country80 target enrollmentAugust 2011

ConditionsAdult Patients Ventilated More Than 48 h Stable Respiratory and Hemodynamic Conditions for SBT Consent of Patients Arterial Line

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Adult Patients Ventilated More Than 48 h
Sponsor: University Hospital, Clermont-Ferrand
Enrollment: 80
Locations: 1
Primary Endpoint: variations of lung ultrasound score
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Detailed Description

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

Registry

clinicaltrials.gov

Start Date

August 2011

End Date

June 2013

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University Hospital, Clermont-Ferrand

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Adult patients ventilated more than 48 h
•Stable respiratory and hemodynamic conditions for SBT
•Consent of patients
•Arterial line

Exclusion Criteria

•Laryngeal dyspnea
•Tracheostomy
•No echogenicity
•Paraplegia \>T8

Outcomes

Primary Outcomes

variations of lung ultrasound score

Time Frame: 24 hours after extubation

Secondary Outcomes

Lung ultrasound score(at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation)
rates of patients with postextubation distress(during the 48th post-extubation)
Electrical Impedance tomography(at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation)
Epithelial and endothelial biomarkers(at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation)