Evaluation of Non Invasive Fetal Cardiac Functions and Fetal Arterial&Venous Doppler Study in Intrauterine Growth Restriction as Predictive Parameters of Perinatal Outcome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fetal Hypoxia
- Sponsor
- Assiut University
- Enrollment
- 534
- Locations
- 1
- Primary Endpoint
- Cerebroplacental ratio
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Intrauterine growth restriction (IUGR) is one of the major contributors to perinatal mortality and morbidity and is characterized by complex hemodynamic changes involving placental and fetal arterial, cardiac and venous circulations .However, the temporal sequence of these modifications in relation to other hemodynamic changes of the fetal arterial and venous circulations is unknown.
The aim of this study was to evaluate cardiac function and other hemodynamic changes in a group of fetuses with IUGR and clinical impact on perinatal outcome .
Investigators
Sief el eslam Ahmed Ali
Principal investigator
Assiut University
Eligibility Criteria
Inclusion Criteria
- •Singleton fetus with normal fetal anatomy documented a detailed sonogram.
- •Fetal abdominal circumference \<5th percentile for gestational age.
- •Evidence of placental insufficiency documented by an elevated umbilical artery pulsatility index (UA-PI) by reference ranges.
Exclusion Criteria
- •evidence of fetal infection
- •chorioamnionitis
- •fetal anomalies
- •abnormal fetal karyotype
- •patient withdrawal from the study and/or unavailability for follow-up.
Outcomes
Primary Outcomes
Cerebroplacental ratio
Time Frame: 5 minutes
cerebroplacental ratio = Rtio middle cerebral artery pulsatility index / umbilical artery pulsatility index
Preload Index in inferior vena cava
Time Frame: 5 minutes
Preload Index in inferior vena cava = ratio of peak systolic velocity in atrial contraction /peak systolic velocity ventricular systole
Myocardial performance index
Time Frame: 5 minutes
Ratio between isovolumetric time to ejection time
Aortic isthmus flow index
Time Frame: 5 minutes
Aortic isthmus flow index = Ratio of (systolic velocity time integral+diastolic velocity time integral) / systolic velocity time integral