Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 692
- 试验地点
- 1
- 主要终点
- Proportion of cycles which obtained euploid blastocysts
研究概览
简要总结
This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients.
Infertile patients aged 38-46 years old were recruited for study if they fulfill the inclusion criteria and do not have the exclusion criteria.
Treatment group: Women received growth hormone (GH) supplement during antagonist protocol for ovarian stimulation.
Control group: Women received antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts per stimulation cycle and per testing cycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 38 Years 至 46 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 38-46; BMI 18.5-24.0kg/m2; intended to undergo PGT-A; GnRH Antagonist protocol for ovarian stimulation; normal semen analysis for the male partner
排除标准
- •Endometriosis grade 3 or higher, untreat hydrosalpinx;
- •Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus uni-cornate, bicornate, or duplex);
- •Untreated uterine septum, adenomyosis, submucous myoma, or endo-metrial polyp(s)
- •Women who are indicated and planned to undergo PGT-SR (Preimplantation genetic testing for structural rearrangement) or PGT-M (Preimplantation genetic testing for monogenic disorder), for example, parental abnormal karyo-type or diagnosed with monogenic disease;
- •Women who received other supplement drugs during ovarian stimulation
研究组 & 干预措施
GH group
Growth Hormone supplement, GnRH antagonist protocol for ovarian stimulation
干预措施: Growth hormone (Drug)
GH group
Growth Hormone supplement, GnRH antagonist protocol for ovarian stimulation
干预措施: GnRH antagonist (Drug)
Control group
No Growth Hormone supplement, GnRH antagonist protocol for ovarian stimulation
干预措施: GnRH antagonist (Drug)
结局指标
主要结局
Proportion of cycles which obtained euploid blastocysts
时间窗: 1 month after oocyte retrieval
Number of cycles with at least 1 euploid blastocyst divided by the total number of stimulation cycles in a cohort
次要结局
- Euploidy rate per cycle(1 month after oocyte retrieval)
- Euploid blastocyst rate per cohort(1 month after oocyte retrieval)