Interval-training and Appetite Regulation in Patients With Type 2 Diabetes

Not Applicable

• Conditions: Diabetes Mellitus, Type 2
• Interventions: Behavioral: CON; Behavioral: IW; Behavioral: CW

• Registration Number: NCT02592616
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.

This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.

Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:

1. One hour of rest (CON)

2. One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)

3. One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.

After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2015-10-28
• Study First Submitted QC: 2015-10-29
• Study First Posted: 2015-10-30
• Status Verified: 2016-06
• Primary Completion: 2016-06
• Last Update Submitted: 2016-06-21
• Last Update Posted: 2016-06-22
• Study Completion: 2016-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Type 2 Diabetes Mellitus
• BMI > 25

Exclusion Criteria

• Pregnancy
• Smoking
• Contraindication to increased levels of physical activity
• Eating disorder
• Insulin dependence

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
CON	CON	Control (CON).
IW	IW	Interval Walking (IW).
CW	CW	Continuous Walking (CW).

Primary Outcome Measures

Name	Time	Method
Ad-libitum meal energy intake	Initiated 3 hours after the intervention	Subjects will receive a standardized ad-libitum meal and energy intake will be assessed

Secondary Outcome Measures

Name	Time	Method
Satiety	Regular assessments for 36 hours following the intervention	Satiety questionaires will be completed at regular intervals after the intervention
Free-living energy intake	For 32 hours following the ad-libitum meal.	Subjects will complete diet records for 32 hours following the ad-libitum meal and energy intake will be assessed.
Appetite-related hormones	Regularly during the 3 hours following the intervention	Appetite-related hormones (insulin, ghrelin, leptin, cholecyctokinin, PYY) will be analysed in blood samples collected regularly during the liquid mixed-meal tolerance test following the intervention

Trial Locations

Locations (1)

Center for Physical Activity Research (CFAS); 🇩🇰 Copenhagen, Denmark