Does inhaled salbutamol decrease the incidence of perioperative respiratory adverse events in children at high risk for respiratory complications?

Phase 4

Completed

• Conditions: The impact of salbutamol vs placebo on the incidence of respiratory complications in children at a particular high risk for respiratory complications; Anaesthesiology - Anaesthetics; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12612000626864
• Lead Sponsor: Princess Margaret Hospital for Children

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-06-12
• Study Completion: 2015-10-09
• Last Update Posted: 6 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 470

Inclusion Criteria

Children, aged 6-16 years, male or female, undergoing elective surgery with a laryngeal mask airway. All children have to have 2 or more risk factors for respiratory complications:
1)Upper respiratory tract infection < 2 weeks prior to surgery
2)eczema at present or in the past
3)wheezing in the last 12 months
4)previous asthma (if wheezing in the past year is negative)
5)dry night cough
6)respiratory symptoms with exercise
7)family history of asthma (mother, father and/or siblings)
8)family history of eczema (mother, father and/or siblings)
9)family history of hayfever(mother, father and/or siblings)
10)passive smoke exposure (mother, father, caregiver)

Exclusion Criteria

Known cardiac disease, airway or thoracic malformations, syndrome, neurological disorder, need for premedication, contraindication for LMA use as assessed by an anaesthetist independent of the study team. Any surgery involving the upper airway, chest or abdomen.

Study & Design

• Study Type: Interventional
• Study Design: Not specified