Uterine Artery Doppler Changes Prior and After Breastfeeding

• Conditions: Breastfeeding
• Interventions: Diagnostic Test: Postpartum ultrasound

• Registration Number: NCT03701633
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

We aim to determine whether there are any differences in the UtA doppler measurements in postpartum women prior and right after breastfeeding.

Detailed Description

There is emerging evidence linking abnormal UtA Doppler indices in the postpartum period as a risk factor for developing future cardiovascular disorders. Thus far, no study considered the postpartum physiology itself as a possible confounder. If one wishes to draw conclusions about future cardiovascular risk, the role of oxytocin as a confounder must be determined. In the current study, we aim to determine whether oxytocin, physiologically produced during breastfeeding, has an effect on the UtA Doppler measurements in the postpartum period.

Study Timeline

• Study First Submitted: 2018-10-08
• Study First Submitted QC: 2018-10-09
• Study First Posted: 2018-10-10
• Study Start: 2018-11-01
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-25
• Last Update Posted: 2018-12-27
• Primary Completion: 2019-10-01
• Study Completion: 2020-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

-Every woman who had vaginal delivery, instrumental delivery or cesarean section.

Exclusion Criteria

-Patient's refusal, women who decided not to breastfeed, women who wish to breastfeed, but in whom no milk production commenced yet.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Prior to breastfeeding - cross section	Postpartum ultrasound	Measurements of the UtA doppler postpartum ultrasound will be carried out twice for each eligible woman on the second day postpartum. The first measurement will take place just prior to a planned breastfeeding. The second measurement will be followed immediately (within 10 min) after the breastfeeding session.
After breastfeeding - cross section	Postpartum ultrasound	Measurements of the UtA doppler postpartum ultrasound will be carried out twice for each eligible woman on the second day postpartum. The first measurement will take place just prior to a planned breastfeeding. The second measurement will be followed immediately (within 10 min) after the breastfeeding session.

Primary Outcome Measures

Name	Time	Method
Postpartum uterine artery doppler changes prior and after breastfeeding.	One year	To determine whether there are any differences in the UtA doppler measurements in postpartum women prior and right after breastfeeding.

Trial Locations

Locations (1)

Rambam health care campus; 🇮🇱 Haifa, Israel