The Effectiveness and Safety of FK-506 for the Treatment of Posner-Schlossman Syndrome
- Conditions
- Posner Schlossman Syndrome
- Interventions
- Registration Number
- NCT04590183
- Lead Sponsor
- Peking University
- Brief Summary
To evaluate the effectiveness and safety of tacrolimus eye drops (FK-506) in the treatment of Posner-Schlossman Syndrome. It is expected to collect 30 patients with PSS who are in the Ophthalmology Department of Peking University Third Hospital. The included PSS patients were divided into experimental group and control group using simple randomization method. Among them, the experimental group was treated with FK-506 twice a day, and the control group was treated with prednisolone acetate ophthalmic suspension 1% 4 times a day.
For all PSS patients whose intraocular pressure is higher than 30mmHg, also add brinzolamide eye drops 3 times a day. Best corrected visual acuity, Goldmann intraocular pressure, anterior section photographs, corneal endothelial cells，corneal confocal microscope, Heidelberg retinal nerve analysis, Octopus visual field were examined on baseline and 1 week, 2 weeks, 3 weeks, 4 weeks after the treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- Clinical diagnosis of PSS Must be able to communicate with doctor and understand this study
- Fuchs syndrome
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description The control group Prednisolone Acetate 1% Oph Susp - The experimental group FK-506 (Drug) -
- Primary Outcome Measures
Name Time Method Silt-lamp examination of the cornea 4 weeks after the treatment KP numbers after the treatment
- Secondary Outcome Measures
Name Time Method Goldmann ophthalmotonometer examination of intra-ocular pressure 4 weeks after the treatment change of intra-ocular pressure
Trial Locations
- Locations (1)
Peking University Third Hosipital
🇨🇳Beijing, Beijing, China