Injection of Hormone to Enhance Implantation in Embryo Transfer After IVF
- Registration Number
- NCT01986374
- Lead Sponsor
- Servy Massey Fertility Insititute
- Brief Summary
The endometrium is deprived of signals form the embryo in IVF conditions. Studies suggest that placing HCG into the uterus prior to embryo transfer can enhance implantation.
- Detailed Description
The study is in pilot phase, uncontrolled. The risks appear to be minimal and there are conflicting new reports being announced.
A small amount of fluid with HCG is injected into the uterus. HCG is a potent signal to the uterus for preparation for implantation.
This is not a funded study. Three published studies suggest the approach is valid; one refutes the concept.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 75
- infertility patients undergoing IVF with good expectation of two embryos day 3 or day 5. must speak and read English. Includes donor eggs.
abnormal uterus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description HCG is introduced with small catheter. HCG is introduced phase 1 non randomized pilot
- Primary Outcome Measures
Name Time Method HCG enhances pregnancy rate 9 months. compare pregnancy rates to established clinical norms.
- Secondary Outcome Measures
Name Time Method ongoing pregnancy rate 22 months compare success to clinical norms
implantation rate 18 months compare implantation rate per embryo to clinical norms.
Trial Locations
- Locations (1)
Servy Massey Fertility Insititute
🇺🇸Atlanta, Georgia, United States