Effect of ondansetron in decreasing occurrence of low blood pressure during caesarean operation in pregnant women with high blood pressure
Not Applicable
- Conditions
- Health Condition 1: O164- Unspecified maternal hypertension,complicating childbirth
- Registration Number
- CTRI/2019/02/017489
- Lead Sponsor
- Safdarjung Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. American Society of Anaesthesiologists physical status II and III women with hypertensive disorders of pregnancy
2. Term singleton pregnancy
3. Scheduled for elective Caesarean delivery under spinal anaesthesia
Exclusion Criteria
1. Eclampsia, HELLP syndrome, diabetes mellitus, valvular heart or cerebrovascular disease
2. Onset of labour, foetal abnormality or distress
3. Allergy to study medication or patients receiving 5-hydroxytryptamine reuptake inhibitors
5. Weight less than 50 kg or more than 100 kg
6. Height less than 140 cm or more than 170 cm
7. Coagulopathy, thrombocytopenia
8. Contraindication to spinal anaesthesia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of ondansetron administration on the incidence and severity of spinal anaesthesia induced hypotension in patients with hypertensive disorders of pregnancy undergoing elective Caesarean deliveryTimepoint: Intraoperative period
- Secondary Outcome Measures
Name Time Method 1. To evaluate the effect of ondansetron administration on the incidence of maternal bradycardia, nausea, vomiting and vasopressor consumption in above patients. <br/ ><br>2. To evaluate the effect of ondansetron administration on neonatal outcome by Apgar scores and umbilical cord blood gas analysis. <br/ ><br>Timepoint: Intraoperative period