Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104,000
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Intraoperative intravenous fluid management practice varies greatly between anesthesiologists. Postoperative fluid based weight gain is associated with major morbidity. Postoperative respiratory complications are associated with increased morbidity, mortality and hospital costs. The literature shows conflicting data regarding intraoperative fluid resuscitation volume. No large-scale studies have focused on intraoperative fluid management and postoperative respiratory dysfunction.
Hypotheses:
Primary - Liberal intraoperative fluid resuscitation is associated with an increased risk of 30 day mortality Secondary - Liberal intraoperative fluid resuscitation is associated with increased likelihood of postoperative respiratory failure, pulmonary edema, reintubation, atelectasis, acute kidney injury and peri-extubation oxygen desaturation.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 18 upwards
- •Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure
排除标准
- •Cases where the subject had additional surgeries within the previous four weeks
- •Ages under 18
结局指标
主要结局
Mortality
时间窗: within 30 days after surgery
Mortality within 30 days of surgery
次要结局
- Post-extubation oxygen desaturation(within the first 10 minutes after extubation)
- Postoperative pulmonary complications(3 days after surgery)
- Acute Kidney Injury(within 48 hours of surgery)
研究者
Matthias Eikermann
M.D., Ph.D.
Massachusetts General Hospital