Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Failure
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 104000
- Locations
- 1
- Primary Endpoint
- Mortality
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Intraoperative intravenous fluid management practice varies greatly between anesthesiologists. Postoperative fluid based weight gain is associated with major morbidity. Postoperative respiratory complications are associated with increased morbidity, mortality and hospital costs. The literature shows conflicting data regarding intraoperative fluid resuscitation volume. No large-scale studies have focused on intraoperative fluid management and postoperative respiratory dysfunction.
Hypotheses:
Primary - Liberal intraoperative fluid resuscitation is associated with an increased risk of 30 day mortality Secondary - Liberal intraoperative fluid resuscitation is associated with increased likelihood of postoperative respiratory failure, pulmonary edema, reintubation, atelectasis, acute kidney injury and peri-extubation oxygen desaturation.
Investigators
Matthias Eikermann
M.D., Ph.D.
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Ages 18 upwards
- •Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure
Exclusion Criteria
- •Cases where the subject had additional surgeries within the previous four weeks
- •Ages under 18
Outcomes
Primary Outcomes
Mortality
Time Frame: within 30 days after surgery
Mortality within 30 days of surgery
Secondary Outcomes
- Post-extubation oxygen desaturation(within the first 10 minutes after extubation)
- Postoperative pulmonary complications(3 days after surgery)
- Acute Kidney Injury(within 48 hours of surgery)