Habituation or sensitization effects of repetitive nociceptive stimuli measured with cortical event related potentials in patients with and without chronic pain after a lumpectomy or mastectomy and an axillary lymph node dissection.
Completed
- Conditions
- Chronische pijnGeneralized hyperalgesiaChronic pain
- Registration Number
- NL-OMON32895
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
Patients after lumpectomy or mastecomy and an axillary lymph node dissection; 1 to 3 years post OK
Patients with pain presented longer than 3 months, will be included in de chronic pain group
Aged 18 - 65 years
Women
Exclusion Criteria
Actual presence of (breast)cancer or metastases.
Presence or history of neurological (other than chronic pain) or major psychiatric diseases.
Regular intake of medication affecting potentially brain function or EEG signal.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>N1-P2 peak-to-peak and P300 amplitudes in the event related potentials (EEG).</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. The quantification of DNIC response 2. The quantification of the subjective<br /><br>intensity of pain 3. The quantification of the nature of pain 4. Baseline<br /><br>parameters: date of birth, date of surgery, treatment technique, medication<br /><br>intake, duration of pain suffering, medical co-morbidity (neurological<br /><br>diseases, psychiatric diseases or diabetes).</p><br>