Controlled randomized double blind study: Comparison of Dexmedetomidine versus Propofol for Maintenance of Anesthesia during invasive procedures In Pediatric Oncology Patients
Phase 1
- Conditions
- pediatric oncologyAnaesthesiology - AnaestheticsCancer - Children's - Leukaemia & Lymphoma
- Registration Number
- ACTRN12613000149763
- Lead Sponsor
- Ahmad ramzy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Children between 6-12years. diagnosed as either acute lymphocytic leukemia or acute myeloid leukemia with ASA physical status I–II scheduled for for diagnostic or prognostic lumbar puncture or bone marrow biopsy. will be eligible for inclusion in the study.
Exclusion Criteria
ASA physical status III–IV, age less than6 years or more than 12 years,congenital heart disease, cardiomyopathy, any rhythm other than sinus rhythm, liver or renal disease, upper respiratory infection, behavioral problems, patient on anticoagulant, beta blocker, clonidine, or digoxin.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency and total dose of ketamine used to keep the intraoperative sedation score of 5-6 Using Ramsay Sedation Score[intraoperative ];post operative recovery profile<br>Recovery excitement score developed by Kegan will be used by the observer to assess degree of agitation upon emerge from sedation (1 -(none)awake and calm, cooperative; 2 –(mild) crying occasionally; 3 –(moderate) irritable/restless, screaming,inconsolable; 4 –(marked) combative, disoriented,thrashing).[immediately postoperative ( at the end of the procedure)]
- Secondary Outcome Measures
Name Time Method hemodynamic stability (Heart rate, oxygen saturation, blood pressure)<br>will be recorded intraoperatively in consecutive 5-min intervals in both groups using( Patex, Ohmeda S/5Avance) standard monitor.[intraoperative]