iving kidney donation and the kinetics of proenkephalin.
- Conditions
- Kidney injury
- Registration Number
- NL-OMON26466
- Lead Sponsor
- Radboudumc
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Male or female > 18 years old
-Living kidney donor
-Baseline kidney function: eGFR > 60 mL/min
-Able and willing to provide informed consent
Exclusion Criteria
No exclusion criteria
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method •PENK plasma concentration prior to and following kidney donation compared to the kinetics of tubular injury markers<br>•Neutrophil gelatinase-associated lipocalin (NGAL) and TIMP-2*IGFBP7 (Nephrocheck) and functional markers (creatinine and cystatin C plasma concentrations)<br>
- Secondary Outcome Measures
Name Time Method •Association between PENK and estimated GFR (using serum creatinine and cystatin C) following kidney donation<br>•Association between PENK and endogenous creatinine clearance after donating kidney.<br>•Association between peak PENK and creatinine concentrations<br>