Dexmedetomidine Versus Triamcinolone Local Injection for Pain Alleviation in Patients With Carpal Tunnel Syndrome; A Randomized Clinical Trial.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- pain visual analoge scale visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain
研究概览
简要总结
Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modalities are available for treatment of mild to moderate CTS.
详细描述
Carpal tunnel syndrome (CTS) is a common mononeuropathy due to entrapment of the median nerve in the carpal tunnel. a lot of modaleties are available for treatment of mild to moderate CTS.
In case of failed conservative oral therapey, local hydro-dessction of the median nerve can be done with saline alone. local anethetics, steroids, hyalase,and ozone have been utilized to augment the symptoms reliefe.
Dexmeditomidine (DEX) has been studied as adjuvant for nerve block to aumnet the pain reliefe. Recently, it has been discovered that DEX can offer some antinflammatory effects when injected in the perineural area. Upon such discovery, the goal of this study has been built.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients
- •complaining of carpal tunnel syndrome of 3 month duration or more
- •diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study
排除标准
- •patient refusal
- •infection at the site of intervention
- •allergy to utilized drugs
- •previous surgery in the site of injection
- •previous injection in the targeted site within the last year
研究组 & 干预措施
Dexmeditomidine group
injection of 1 microgram/kg dexmeditomidine + 10 cc saline injection nearby median nerve as hydro-dissection
干预措施: Dexmedetomidine (Drug)
Triamcinolone group
injection of 40 mg triamcinolone + 10 cc saline injection nearby median nerve as hydro-dissection
干预措施: Triamcinolone (Drug)
结局指标
主要结局
pain visual analoge scale visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain
时间窗: 6 months
visual analog scale of pain value of (0 cm) no pain , and value of (10 cm) worst pain
次要结局
- change of cross sectional area of the median nerve(6 months)
研究者
Emad Zarief , MD
Professor
Assiut University