Post -Extubation Respiratory Failure
- Conditions
- Respiratory Insufficiency
- Interventions
- Device: High flow nasal cannula
- Registration Number
- NCT04441736
- Lead Sponsor
- Cairo University
- Brief Summary
comparing high flow nasal cannula , conventional oxygen tharapy and non invasive ventilation post-extubation period for patients mechanically ventilated due to respiratory failure regarding re-intubation rate, ICU outcome \& 28 days mortality
- Detailed Description
patients with respiratory failure either type I or type II planned for extubation will be divided into 3 groups post extubation :
Group I: will receive high flow nasal cannula giving oxygen 60 litres / minute flow group II: will receive nasal cannula up to 10 litres / minute group III: will receive non invasive ventilation
Data of the patients will be collected for 28 days post-extubation and analysed
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- respiratory failure type I and Type II
- Mechanical ventilation due to other cause such as disturbed conscious level or respiratory muscle weakness
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description High flow nasal cannula High flow nasal cannula A device of high flow nasal cannula giving 60 litres / min flow Conventional oxygen High flow nasal cannula Nasal cannula giving oxygen up to 10 litres / minute Non invasive ventilation High flow nasal cannula non invasive ventilation with IPAP and EPAP
- Primary Outcome Measures
Name Time Method Number of participants with post extubation respiratory failure 7 days Number of participants with post extubation hypoxemia with or without hypercapnea
- Secondary Outcome Measures
Name Time Method Rate of ICU stay and mortality 28 days Duration of ICU stay and incidence of mortality
Trial Locations
- Locations (1)
Faculty of Medicine
🇪🇬Giza, Egypt