Satiety Effects on the Neural Valuation of Food

Completed

• Conditions: Fasting; Fed

• Registration Number: NCT01721187
• Lead Sponsor: Duke-NUS Graduate Medical School

Brief Summary

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2012-10-23
• Study First Submitted QC: 2012-11-01
• Study First Posted: 2012-11-04
• Primary Completion: 2013-12
• Study Completion: 2014-07
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-04
• Last Update Posted: 2015-08-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Chinese ethnicity
• 21 to 45 years old
• English as first language
• Right-handed
• Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
• Weigh less than 100kg with an abdominal circumference of less than 120cm
• Non-smoker, or only smoke occasionally (less than 5 sticks a week)
• Consume less than 2 units (200 mg) of caffeine a day
• Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
• Habitually sleep before 1am and wake before 9am

Exclusion Criteria

• On a restrictive diet (e.g., vegetarian/vegan diet)
• History of food allergies
• History of psychiatric or neurological disorders
• History of chronic medical illness
• Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
• Shift worker
• Claustrophobic
• High astigmatism (high = >2.00 diopters)
• Colour-blind

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
fMRI - Monetary and Food Incentive Delay task	Fed and fasted visits (Wks 1 & 2)	A measurement of neural response to anticipating and receiving money and food rewards.
fMRI - Willingness to Pay task (BDM auction)	Fed and fasted visits (Wks 1 & 2)	A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.

Trial Locations

Locations (1)

Centre for Cognitive Neuroscience scanner suite; 🇸🇬 Singapore, Singapore