Analysis of the Pseudomonas aeruginosa biofilm in the respiratory samples of cystic fibrosis patients
Completed
- Conditions
- Cystic fibrosis / Pseudomonas aeruginosa biofilm / Intrapulmonary Percussive Ventilation (IPV)Nutritional, Metabolic, EndocrineCystic fibrosis, unspecified
- Registration Number
- ISRCTN75391385
- Lead Sponsor
- Belgian Cystic Fibrosis Association (BCFA) (Belgium)
- Brief Summary
2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29560543
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
1. CF patients (diagnosis confirmed by sweat test)
2. Age greater than 6 years, upper age limit 60 years
3. Hospitalisation 3 to 4 times a year for routine intravenous (IV) antibiotic treatment
4. Clinically stable at time of study entry
Exclusion Criteria
1. Lung transplantation
2. Massive hemoptysis
3. Pneumothorax
4. Pregnancy
5. Non-invasive and invasive ventilation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Analysis of P. aeruginosa abundance, physiology, virulence factors and gene expression on day 1, day 4 and day 10 of each hospitalisation
- Secondary Outcome Measures
Name Time Method ung function values [Forced expiratory volume in the first one second (FEV1) and forced vital capacity (FVC)] on day 1 and day 10 of each hospitalisation