Effects of Infant Egg Consumption on Child Health and Cognition Development
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5,374
- 试验地点
- 1
- 主要终点
- Fat mass
研究概览
简要总结
The objective of this study is to examine how infant egg consumption (age of introduction and frequency of intake) influences physical growth, obesity, cardio-metabolic health, risk of food allergy, and cognition development in mid-childhood and adolescence.
详细描述
The investigators will use existing data from two US longitudinal birth cohorts that tracked mother-child dyads from pregnancy to adolescence: 1) Project Viva (1999-present) that enrolled 2,341 pregnancies and followed 2,128 children at delivery, 6 months, then yearly from 1 year to 15 years of child age, and 2) the Infant Feeding Practices Study II (IFPS II, 2005-2007) that enrolled 3,033 pregnancies with surveys in late pregnancy, neonatal (1 month), then monthly from 2 months (N=2,552) to 12 months of infant age, and at 6 years. For Aim 1, the investigators will classify infants based on their age of egg introduction: never, <2 months, 2-3 months, 4-5 months, 6-8 months, 9-11 months, and 12 months. The investigators will compare physical growth, obesity, cardio-metabolic health, food allergy, and cognition test scores in mid-childhood and adolescence. The investigators will fit multi-variable linear or logistic regression models with fractional polynomial functions of the infant age of egg introduction. Both linear (e.g., earlier introduction, a higher probability of the outcome) and non-linear (e.g., threshold effect) associations will be tested. For Aim 2, The investigators will classify infants based on their frequency of egg intake: never, <once/week, once/week, 2-4 times/week, nearly daily or daily, and 2 times/day. The investigators will use similar analytic methods mentioned above to compare their later outcomes. Finally, the investigators will create an average probability of multiple child outcomes to balance across different aspects of child health and development. The investigators will identify the lowest-risk infant egg consumption when the corresponding average predicted probability of the related adverse outcomes is the lowest.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children with complete data on infant egg consumption and the corresponding health and cognition outcomes.
排除标准
- 未提供
结局指标
主要结局
Fat mass
时间窗: 14-15 years
Research staff measured children's fat mass in Project Viva.
Lean mass
时间窗: 14-15 years
Research staff measured children's lean mass in Project Viva.
Trunk fat mass
时间窗: 14-15 years
Research staff measured children's trunk fat mass in Project Viva.
Systolic blood pressure
时间窗: 14-15 years (mid-teen)
Research staff measured children's systolic blood pressure in Project Viva.
Diastolic blood pressure
时间窗: 14-15 years (mid-teen)
Research staff measured children's diastolic blood pressure in Project Viva.
Weight
时间窗: 6 years
In IFPS II, mothers reported infant weight in survey.
Height
时间窗: 6 years
In IFPS II, mothers reported infant height in survey.
Waist Circumference
时间窗: 14-15 years
Research staff measured children's waist circumference in Project Viva.
Skinfold thickness
时间窗: 14-15 years
Research staff measured children's skinfold thickness in Project Viva.
Diagnosis of food allergy
时间窗: 6 years
In the IFPS-II mothers reported the child's food allergy.
Intelligence (PPVT-III test)
时间窗: 3 years
In Project Viva, trained research staff administered the Peabody Picture Vocabulary Test-3rd edition (PPVT-III, a test of receptive language) at 3 years of age.
Intelligence (KBIT-II test)
时间窗: 7 years
In Project Viva, trained research staff administered the Kaufman Brief Intelligence Test-2nd edition (KBIT-II, verbal and non-verbal intelligence) at 7 years of age.
Visual-motor (WRAVMA)
时间窗: 7 years
Research staff measured children's visual-motor in Project Viva. At the 7-years visit, staff administered the WRAVMA visual motor (drawing) subtest only.
Memory-learning
时间窗: 7 years
Research staff measured children's memory-learning in Project Viva. For the memory-learning domain, staff administered the design memory and picture memory subsets of Wide Range Assessment of Memory and Learning (WRAML) at the 7-years visit.
次要结局
未报告次要终点
研究者
Xiaozhong Wen
Principal Investigator
State University of New York at Buffalo