The effect of warm saline irrigation on mucociliary function in patients with chronic rhinosinusitis

Not Applicable

Completed

• Conditions: anterior rhinomanometry, Chronic rhinosinusitis patients; saline nasal irrigation, chronic rhinosinusitis, mucociliary function, saccharin transit time, ciliary beat, nasal obstruction, acoustic rhinometry, peak inspiratory flow&#44

• Registration Number: TCTR20140323002
• Lead Sponsor: Department of Otorhinolaryngology, Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03-23
• Study Completion: 2015-02-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Chronic rhinosinusitis patients fulfill EPOS2012 criterias
Has moderate or severe severity (by visual analog scale more than 5)
No recent sinusitis treatment within 1 month

Exclusion Criteria

Has been diagnosed with congenital mucociliary or mucosal diseases e.g. Primary ciliary dyskinesia, cystic fibrosis
has been diagnosed with immuno-deficiency disease e.g. diabetes mellitus, AIDS
Large nasal polyp (grade 3)
Fungal rhinosinusitis or fungal ball
has been diagnosed with systemic vasculitis or granulomatous disease
History of Cocaine abuse
Has been diagnosed with tumor in nasal cavity or paranasal sunus
Has severe nasal septum deviation that may interfere nasal irrigation
Recent medication that may alter muciliary function e.g. 1st generation antihistamine within 3 days

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mucociliary clearance 1 hour Saccharine transit time

Secondary Outcome Measures

Name	Time	Method
Symptom score 1 hour obstructive symptom score,Comfortability 1 hour comfortability symptom score,Objective score 1 hour peak nasal inspiratory flow,Objective score 1 hour rhinomanometry,Objective score 1 hour acoustic rhinometry