Fluid Management Strategies on Blood Loss in Liver Transplantation

Not Applicable

Recruiting

• Conditions: Liver Transplant
• Interventions: Other: Liberal group; Other: restrictive group

• Registration Number: NCT06215404
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

During liver transplantation, due to the complexity of the operation and abnormal coagulation function, there may be a large amount of bleeding and corresponding blood transfusion. Excessive blood transfusion will increase pulmonary complications and affect the prognosis. Infusion management to reduce bleeding is a very important issue in liver transplant surgery. Restrictive infusion management can effectively reduce the amount of bleeding in liver transplantation, but it remains unclear whether it will cause sequelae in other major organs.

The investigators plan to study different infusion goals and strategies in liver transplant surgery using a randomized group model, using the PiCCO (Pulse Contour Cardiac Output) cardiopulmonary volume monitor, and setting the stroke volume variation (SVV) as the macroscopic circulation.The purpose of this study was to divide it into restrictive and liberal groups to explore the impact on liver transplantation bleeding volume and inflammatory response as well as postoperative lung and renal function, and to collect statistics on clinical care and postoperative sequelae (pulmonary liver, renal function impairment, etc.) in order to develop the most appropriate infusion management strategy in liver transplantation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-01-10
• Study First Submitted QC: 2024-01-10
• Study Start: 2024-01-15
• Study First Posted: 2024-01-22
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-08
• Last Update Posted: 2025-04-11
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• end stage liver disease
• age between 18y/o to 75 y/o
• expected to recieve to receive liver transplantation

Exclusion Criteria

• arrythmia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Liberal group	Liberal group	stroke volume variation \< 10%
restrictive group	restrictive group	stroke volume variation \< 18%

Primary Outcome Measures

Name	Time	Method
blood loss intraoperatively	during the operation	blood loss intraoperatively in liver transplant

Secondary Outcome Measures

Name	Time	Method
Lung injury biomarker	from biginning of the operation to postoprative day 1	serum Clara Cell Protein (CC16)
Kidney injury biomarker	from biginning of the operation to postoprative day 1	serum Neutrophil Gelatinase Associated Lipocalins (NGALs)
Influammatory reponses	from biginning of the operation to postoprative day 1	IL-6

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan