Association of Sarcopenia With Quality of Life and Progression of Disease in Patients With Idiopathic Pulmonary Fibrosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Hand Grip Strength
研究概览
简要总结
Sarcopenia negatively affects the prognosis of chronic diseases. However, the importance of sarcopenia in patients with idiopathic pulmonary fibrosis (IPF) has been less emphasized. The aim of the study is to determine the prevalence of sarcopenia in patients with IPF and to evaluate the impact of sarcopenia on quality of life and disease progression.
This study was designed as a descriptive cross-sectional. The study included patients diagnosed with IPF. Hand dynamometry and bioelectrical impedance analysis (BIA) were used to for diagnose of sarcopenia. Pulmonary function tests, maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) measurements were examined. The 6-minute walk distance (6MWD) and 4-meter walking speed were recorded. The St. George Respiratory Questionnaire (SGRQ) was used to assess quality of life. All patients were evaluated for progressive disease.
详细描述
The study was designed as a cross-sectional study.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being over 18 years of age
- •Signing the informed consent form
- •Having a diagnosis of IPF for at least one month
排除标准
- •Pregnancy
- •History of cancer within the last 5 years
- •History of lung surgery
- •History of neuromuscular disease
- •Active pulmonary tuberculosis
- •Active respiratory tract infection
- •Inability to perform pulmonary function tests
- •Presence of a pacemaker
- •History of systemic steroid use within the past 3 months
- •Inability to use a hand dynamometer
结局指标
主要结局
Hand Grip Strength
时间窗: through study completion, an average of 1 year
Hand Grip Strength (kg)- Grip strength measurement using a hand dynamometer
SMI (skeletal muscle mass index)
时间窗: through study completion, an average of 1 year
SMI (skeletal muscle mass index) (kg/m2) - SMI measurement using the Bioelectrical Impedance Analysis (BIA) device
Forced Expiratory Volume in 1 second (FEV1)
时间窗: through study completion, an average of 1 year
Measurement of FEV1 for the assessment of pulmonary function
Forced Vital Capacity (FVC)
时间窗: through study completion, an average of 1 year
Measurement of FVC for the assessment of pulmonary function
Diffusing Capacity of The Lungs for Carbon Monoxide (DLCO)
时间窗: through study completion, an average of 1 year
Measurement of DLCO for the assessment of pulmonary function.
Total Lung Capacity (TLC)
时间窗: through study completion, an average of 1 year
Measurement of TLC for the assessment of pulmonary function.
Respiratory Muscle Strength
时间窗: through study completion, an average of 1 year
Measurement of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) for assessment of respiratory muscle strength
Six Minute Walk Test (6MWT)
时间窗: through study completion, an average of 1 year
Distance walked in six minutes (m)
Gait speed
时间窗: through study completion, an average of 1 year
4-meter walking speed (m/s)
St. George's Respiratory Questionnaire (SGRQ)
时间窗: through study completion, an average of 1 year
The questionnaire is designed to measure quality of life. It consists of symptom, activity, impact, and total scores. Each score ranges from 0 to 100. High scores indicate lower quality of life.
Progressive Disease
时间窗: through study completion, an average of 1 year
Examination of all participants from clinical, physiological, and radiological perspectives
次要结局
- Body Mass Index ( BMI)(through study completion, an average of 1 year)