Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial

Phase 3

• Conditions: Circulatory System; Nutritional, Metabolic, Endocrine; Surgery; Cardiology; Anaesthesia

• Registration Number: PACTR202303692483097
• Lead Sponsor: cardiothoracic academy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-03-14
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

•All urgent cases of coronary artery bypass surgery whether isolated or combined with mitral valve surgery.
•Uncontrolled diabetes mellitus with Hb A1C >7.0
•ASA physical status 2-5
•Sex (males and females)
•Age 18-70 years.

Exclusion Criteria

•Patients are refusing to participate in the study.
•Below 18 or above 60 years.
•Patients with preoperative abnormal hepatic profiles identified by double average values of ALT/AST or bilirubin or hypoalbuminemia
•Patients with preoperative renal impairment identified by serum creatinine of more than 1.7 mg/dL
•Patient with a history of malignant tumors.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean intraoperative glucose level.

Secondary Outcome Measures

Name	Time	Method
•Perioperative dynamic of troponin I ;•Total insulin infusion in first 24 hours;•Incidence of diabetic ketoacidosis