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Heart Rate During Exercise in Type 2 Diabetes

Not Applicable
Completed
Conditions
Type2 Diabetes Mellitus
Heart Rate
Hyperglycemia
Exercise Training
Interventions
Other: Behavioral
Other: Exercise training intervention
Registration Number
NCT03917576
Lead Sponsor
Universidad de Los Lagos
Brief Summary

Exercise training is a cornerstone for the prevention and treatment of metabolic disorders and associated cardiometabolic complications such as type 2 diabetes mellitus (T2D) and hypertension. Similar to the beneficial health effects after performing conventional continuous exercise modalities, high intensity interval training (HIIT) has been reported as an effective alternative exercise-modality to improve glucose homeostasis in both prediabetes subjects and individuals with T2D diagnosed. In this regard, although multiple HIIT-based interventions commonly report acute and long term benefits on body composition, cardiorespiratory fitness and insulin sensitivity in metabolically compromised subjects, little is known about the acute cardiovascular response (i.e., at heart rate level) during HIIT in subjects with different glucose control.

HIIT is described as performing brief periods of exercise at vigorous or maximal intensity, interspersed with inactive or low intensity recovery phases of variable duration. In order to characterize different HIIT-based protocols, exercise intensity is usually defined as relative percentages of individual maximal cardiorespiratory fitness (VO2max) or relative maximal power output values. Nevertheless, the need for specific technological equipment to assess these parameters usually limit the prescription and recommendations of HIIT in clinical settings and other public health contexts at massive level. Additionally, the use of self-perceived exertion scales and heart rate (HR) variations upon HIIT have been demonstrating to be accessible and feasible strategies to regulate exercise intensity during HIIT. For example, it was reported that HR and self-perceived exertion scores increased progressively in T2D subjects, parallel to the oxygen consumption rate throughout an acute HIIT session performed on cycle ergometer. Consequently, it is conceivable to hypothesize that determining HR variations during HIIT might optimize the recommendation of this training methodology in metabolically compromised subjects as those at risk or with T2D diagnosed. Therefore, the aim of the present study was To describe and compare the acute heart rate changes in response to an incremental maximal exercise test and a single HIIT session between normoglycaemic (NG), prediabetes (Pre-T2D) and type 2 diabetes mellitus (T2D) subjects.

Detailed Description

This cross-sectional study will use a non-probabilistic sample of 75 adult subjects, characterized as healthy normoglycaemic and others with disturbed glucose homeostasis subjects, all referred by a physician to the exercise programme of our research centre. The present study will be carried out in accordance with the Declaration of Helsinki and was approved by the Scientific Ethics Committee of the Universidad de La Frontera. All volunteers read and signed an informed consent. The inclusion criteria will be; a) aged 18-60 y; b) previously screened by physician professional; c) diagnosed with normoglycaemic, prediabetes or T2D state; d) and living in Temuco city. The exclusion criteria will be; a) low maximal cardiorespiratory fitness (defined as VO2max ≤21 ml/kg-1/min-1) below the expected value for the subject's sex and age 11; b) not receiving pharmacologic hypotensive treatment with β-blockers; and c) having no musculoskeletal limitations to perform exercise cycling. The total sample size will be divided in three groups according to the standard glycaemic classification 12; normoglycaemic (NG, n = 32), pre-diabetes (Pre-T2D, n = 30) and type 2 diabetes (T2D, n = 13). The study considered three stages of measurements (enrollment, exercise test, single HIIT session).

Recruitment & Eligibility

Status
COMPLETED
Sex
Female
Target Recruitment
75
Inclusion Criteria
  • aged 18-60 y
  • previously screened by physician professional
  • diagnosed with normoglycaemic, prediabetes or T2D state
  • living in Temuco city
Exclusion Criteria
  • low maximal cardiorespiratory fitness (defined as VO2max ≤21 ml/kg-1/min-1) below the expected value for the subject's sex and age
  • not receiving pharmacologic hypotensive treatment with β-blockers
  • having no musculoskeletal limitations to perform exercise cycling

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Experimental groupBehavioralExperimental Type 2 Diabetes Mellitus Group
Normoglicamic groupExercise training interventionControl normoglycaemic participants
Hyperglicaemic groupExercise training interventionControl hyperglicaemic group
Primary Outcome Measures
NameTimeMethod
Maximum heart rate12 weeks

Measured before and after 12 weeks of high-intensity interval training

Secondary Outcome Measures
NameTimeMethod
Resting heart rate12 weeks

Measured before and after 12 weeks of high-intensity interval training

Heart rate post each HIIT-interval12 weeks

Measured before and after 12 weeks of high-intensity interval training

Heart rate pre each HIIT-interval12 weeks

Measured before and after 12 weeks of high-intensity interval training

Trial Locations

Locations (1)

Cristian ALvarez

🇨🇱

Osorno, Chile

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