Interindividual Variation in Excretion of Curcumin

Not Applicable

Completed

• Conditions: Metabolites; Gut Microbiota
• Interventions: Dietary Supplement: curcumin

• Registration Number: NCT03746158
• Lead Sponsor: University of Massachusetts, Amherst

Brief Summary

The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-09-01
• Study First Submitted: 2018-11-15
• Study First Submitted QC: 2018-11-15
• Study First Posted: 2018-11-19
• Primary Completion: 2019-03-01
• Study Completion: 2019-10-01
• Status Verified: 2020-03
• Last Update Submitted: 2020-12-14
• Last Update Posted: 2020-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• 18-30 year old healthy adults

Exclusion Criteria

• Exclusion criteria included those who are <18 or >30 years old, have a BMI of <20 or >29 kg/m2, have a weight change >4.5 kg in the past 3 months, exceed exercise activities of a curcumin level over the past 3 months, have any diseases, especially intestinal disorders, had abnormal liver or kidney function tests. Those who smoke, consume more than two alcoholic drinks per day, use medication affecting gut microbiota profile (e.g., antibiotics and probiotics) in past three months will also be excluded.
• Additionally, this study excludes menopausal women, those using hormone-based contraceptives, those with abnormal menstrual cycles, and those who are pregnant, lactating or planning to become pregnant.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Curcumin	curcumin	subjects will be assigned to consume one capsule of curcumin (330 mg of curcumin per capsule) three times a day (one capsule with each meal).

Primary Outcome Measures

Name	Time	Method
Determine the concentration of curcumin and its metabolites in the human fecal samples.	3-4 weeks	Utilize LC-MSMS to identify and quantify the curcumin and its metabolites in the subjects fecal samples.

Trial Locations

Locations (1)

Institute for Applied Life Sciences; 🇺🇸 Amherst, Massachusetts, United States