Effect of YAG Vitreolysis Laser treatment on vision-degrading vitreous floaters in short-sighted patients or patients with a posterior vitreous detachment

Not Applicable

• Conditions: Treatment of floaters in the vitreous in patients with bothersome symptoms; Eye Diseases

• Registration Number: ISRCTN72173816
• Lead Sponsor: The Retina Clinic London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-27
• Last Update Posted: 27 May 2024
• Study Completion: 2025-11-05

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Able and willing to give informed consent.
2. Age =18 years
3. Suffering from symptomatic vitreous floaters visible on contact lens biomicroscopy in one or both eyes.
4. Floaters arising from either/both:
4.1. Myopic vitreopathy
4.2. Posterior vitreous detachment

Exclusion Criteria

1. Present with vitreous opacities outside of the described safety area described in section 3.1.1 (i.e., 3 mm vicinity of the retina and 6 mm vicinity of the lens).
2. Visually significant cataract that either causes sufficient media opacity to reduce quality of imaging or would require surgery during the study follow up period.
3. High risk of peripheral lesions requiring treatment at the discretion of the local PI during the study period (if patients require and receive treatment for these at screening, they may be rescreened after 2 months following procedure, at the discretion of the PI).
4. Vitreous floaters or PVD symptoms present for less than three months.
5. Unable to attend study appointments.
6. Synchysis scintillans.
7. Asteroid hyalosis.
8. Vitreous haemorrhage.
9. Active photopsia.
10. Active uveitis.
11. Active proliferative diabetic retinopathy, and/or other significant retinal vascular pathology
12. Pre-existing visual field loss (including uncontrolled glaucoma).
13. Inherited retinal diseases.
14. History of, or active ocular trauma/penetrating ocular injury.
15. Any significant vitreoretinopathy e.g., current or previous retinal detachment, epiretinal membrane, macular hole.
16. History of previous YAG laser vitreolysis treatments, or previous vitreoretinal surgery for any condition (such as retinal detachment, proliferative diabetic retinopathy).
17. History of complicated cataract surgery (e.g anterior vitrectomy).
18. History of intraocular surgery within 6 months from starting the study.
19. Any other significant ocular or non-ocular condition that, at the discretion of the local PI, puts the subject at risk or influences the results of the study.
20. Patients who, in the opinion of the investigator, would be unwilling or unable to provide written informed consent, or undergo the testing procedures as described in the protocol.
21. Pregnant or breastfeeding women

Study & Design

• Study Type: Interventional
• Study Design: Not specified