Correlation of Hyperghrelinemia With Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndrome

Completed

• Conditions: Prader Willi Syndrome; Obesity

• Registration Number: NCT00474643
• Lead Sponsor: Samsung Medical Center

Brief Summary

Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.To assess the significance of risk factors for future disabilities, carotid artery intima-media thickness (IMT) was measured and correlated with known atherosclerotic risk factors in 27 children with PWS and 24 age-, sex-, and body mass index (BMI)-adjusted controls.

Detailed Description

Main outcome measures: Correlation of IMT with age, standard deviation score of BMI (BMI-SDS), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), C-reactive protein, HOMA-IR and ghrelin.

Study Timeline

• Study Start: 2006-08
• Study Completion: 2006-12
• Status Verified: 2007-05
• Study First Submitted: 2007-05-10
• Study First Submitted QC: 2007-05-15
• Last Update Submitted: 2007-05-15
• Study First Posted: 2007-05-17
• Last Update Posted: 2007-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• Prader Willi syndrome
• Children with obesity

Exclusion Criteria

• Acute illness
• On regular medications except growth hormone

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified