effects of L-carnitine on kidneyl graft functio
Phase 2
- Conditions
- kidney transplantation.Kidney transplant failure and rejection
- Registration Number
- IRCT201312233043N9
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Inclusion Criteria:
1. Subjects who are planned to recieve kidney transplantation
2. Subjects of 14-70 years old
Exclusion Criteria
1. Intercurrent acute and severe infections eg: septic shock, myocarditis, acute pancreatitis
2. History of allergy to carnitine or its analogues
3. History of seizure or at high risk for seizure
4. Intercurrent cardiac/hepatic/pulmonary instability during few days after transplantation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma NGAL level. Timepoint: baseline and 2,6,12, 24 and 96 hours after transplantation. Method of measurement: ELISA.;Plasma carnitine level. Timepoint: baseline and 96 hours after transplantation. Method of measurement: ELISA.;Delayed graft function. Timepoint: during first week after transplantation. Method of measurement: Scr, urine output, need for dialysis.
- Secondary Outcome Measures
Name Time Method Serum sodium concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: ISE.;Serum creatinine concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: Jaffe method.;Acute rejection during 2 months after transplantation. Timepoint: during first and second month. Method of measurement: serum creatinine.;Serum potassium concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: ISE.