The Effectiveness of Ketogenic Diet in Preventing or Improving Thrombocytopenia in Cancer Patients Undergoing Chemotherapy: a Randomized Controlled Single Blind Study
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Ketogenic Diet
- Sponsor
- Baoling Guo
- Enrollment
- 80
- Primary Endpoint
- thrombocytopenia
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The main purpose of this study is to evaluate whether dietary intervention through ketogenic diet can prevent or improve chemotherapy related thrombocytopenia in cancer patients.
Detailed Description
In the study, 80 patients with malignant solid tumors undergoing chemotherapy were randomly assigned to the normal diet group, the strict ketogenic diet group, the circulating ketogenic diet group, and the autonomous ketogenic group. During the chemotherapy period, the corresponding dietary intervention was carried out, and the clinical data of patients before and after treatment were collected, including blood routine, blood ketone concentration, weight, blood sugar, blood lipids, adverse events, and changes in platelets before and after chemotherapy, Statistical analysis of data such as the change degree of platelets and the incidence of adverse events in each diet group before and after treatment was carried out to evaluate the impact of ketogenic diet on clinical indicators and adverse reactions of chemotherapy in cancer patients.
Investigators
Baoling Guo
associate chief physician
Fujian Medical University
Eligibility Criteria
Inclusion Criteria
- •Between the ages of 18 and 90, regardless of gender
- •ECOG score ≤ 2 points
- •Received or expected to receive radiotherapy and chemotherapy during tumor activity
- •Body mass index 19-29
- •Conscious and autonomous eaters
Exclusion Criteria
- •Patients with basic diseases of diabetes
- •Complications such as severe liver and kidney dysfunction or digestive tract obstruction, inability to eat
- •Those who have a preference for food and have strict requirements for dietary taste
- •Disagree to sign informed consent
- •Those whose physical conditions are determined by the doctor to be impermissible
Outcomes
Primary Outcomes
thrombocytopenia
Time Frame: During radiotherapy and chemotherapy, approximately 3 months