Inflammatory markers for prognosis of sepsis and septic shock
Not Applicable
- Conditions
- Health Condition 1: A419- Sepsis, unspecified organism
- Registration Number
- CTRI/2021/09/036242
- Lead Sponsor
- Dr B L Kapur Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients admitted in Medical ICU with a suspected diagnosis of Sepsis and Septic Shock, with likely stay >72 hours.
Exclusion Criteria
1.Patients undergoing any emergency surgery.
2. Patients with a diagnosis of cancer or undergoing therapy for cancer.
3. Pregnant patients
4. Extremely critical patients: Refractory shock, Severe refractory metabolic acidosis
(pH <7.0), persistent hypoxemia (PaO2 ( <50 mm Hg), Multiorgan failure on presentation (3
or more organ failures on presentation), APACHE II >35, SOFA >20.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prognostic value of Procalcitonin (PCT), C-Reactive Protein (CRP) and <br/ ><br>Interleukin-6 (IL-6) in patients with sepsis and septic shockTimepoint: Day 1,Day 3,Day 7 and day 12
- Secondary Outcome Measures
Name Time Method To assess correlation Procalcitonin (PCT), C-Reactive Protein (CRP) and <br/ ><br>Interleukin-6 (IL-6) with disease severity scoring systems- Acute <br/ ><br>Physiology & Chronic Health Evaluation II (APACHE II) and Sequential <br/ ><br>Organ Failure Assessment score (SOFA).Timepoint: The APACHE II score will be <br/ ><br>collected once only after 24-hour of admission to ICU. SOFA scores of Day1, 3, 7 and 12 will be taken into consideration.