Measuring airway smooth muscle using optical coherence tomography in patients undergoing bronchoscopy – an observation study.

Not Applicable

Recruiting

• Conditions: Asthma; Respiratory - Asthma

• Registration Number: ACTRN12622001084774
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-04
• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Participants will be Patients undergoing bronchoscopy for clinical purposes.

Exclusion Criteria

1.Unable to complete questionnaires (language or intellectual difficulties).
2.Central airway obstruction due to tumour or foreign body.
3.Generalised lung disease (e.g. pneumonia, interstitial lung disease, pneumonitis, bronchiectasis or widespread pulmonary infiltrates.
4.Significant concurrent medical illness or treatment with systemic effects (e.g. cardiac disease, cancer, chemotherapy, pulmonary fibrosis).
5.Pregnant women

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We aim to measure the area of airway smooth muscle in large airways of the lung using endoscopic polarisation-sensitive optical coherence tomography. <br><br><br>[ Measurements of airway smooth muscle area / thickness will be assessed during the bronchoscopy. <br>];We also aim to measure the area of airway smooth muscle in the smaller airways using endoscopic polarisation-sensitive optical coherence tomography<br>[ Measurements of airway smooth muscle area / thickness will be assessed during the bronchoscopy. ]

Secondary Outcome Measures

Name	Time	Method
A[ NA]