Comparison of meibomian gland dysfunction in entropion patient after treatment with Quickert suture and medical treatment
Phase 2
- Conditions
- Spastic or involutional entropion patients with meibomian gland dysfunction requiring eyelid surgery.spastic entropion, involutional entropion, meibomian gland dysfunction, Quickert suture, dry eye, lipid layer thickness, tear stability
- Registration Number
- TCTR20240507002
- Lead Sponsor
- Mettapracharak Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1. Thai citizens who are 18 years of age and above
2. Spastic or involutional entropion with meibomian gland dysfuction
3. Require entropion eyelid surgical repair
Exclusion Criteria
1. History of eyelid surgery
2. Appointment of eyelid surgery is within the next 6 months
3. Chronic inflammatory eye diseases that are poor controlled, such as Thyroid eye disease or Steven Johnson syndrome
4. Allergic to fluorescein
5. The patient is unable to follow up as per protocol
6. The patient is unable to communicate the ocular symptoms
7. The patient denys further treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Meibomian gland dropout Baseline, 1 week, 1 month, 3 months, 6 months Grading system by Gestalt method,Lower eyelid lipid layer thickness Baseline, 1 week, 1 month, 3 months, 6 months Interferometry color unit (ICU)
- Secondary Outcome Measures
Name Time Method id margin abnormalities: Telangiectasia, irregularity, thickness, plugging Baseline, 1 week, 1 month, 3 months, 6 months score,Fluorescein staining Baseline, 1 week, 1 month, 3 months, 6 months score,Fluorescein breakup time Baseline, 1 week, 1 month, 3 months, 6 months seconds,Schirmer test Baseline, 1 week, 1 month, 3 months, 6 months millimeters,Tear meniscus height Baseline, 1 week, 1 month, 3 months, 6 months millimeters,Meibum grade Baseline, 1 week, 1 month, 3 months, 6 months grade,Expressed meibum color: upper eyelid, lower eyelid Baseline, 1 week, 1 month, 3 months, 6 months grade,Expressed meibum consistency: upper eyelid, lower eyelid Baseline, 1 week, 1 month, 3 months, 6 months grade