The Effect of Peroperative Fluid Management Strategy on Postoperative Renal Functions in Major Gyneco-oncological Surgeries
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fluid Overload
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Evaluation of acute kidney injury
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this study is to evaluate the effect of perioperative fluid management on postoperative kidney damage in gynecological cancer surgeries.
The main question[s] it aims to answer are:
Does fluid management applied with different hemodynamic monitoring methods affect the risk of postoperative AKI? In our clinic, three different fluid management strategies are applied depending on the anesthetist experience. Acute kidney injury will be evaluated according to the postoperative AKIN classification of conventional fluid therapy and targeted fluid therapy with noninvasive or minimally invasive monitoring.
Detailed Description
Our study was designed as a retrospective study. The files of patients over the age of 18 who underwent open abdominal surgery due to ASAII and III gynecological malignancy will be examined retrospectively. Patients who cannot be monitored peroperatively and who undergo HIPEC will be excluded from the study. Patients will be divided into 3 groups according to the fluid management strategy and the hemodynamic monitoring used: Group 1: patients receiving conventional fluid therapy; Group 2: patients receiving targeted fluid therapy with noninvasive monitoring; Group 3: patients receiving targeted fluid therapy with minimally invasive monitoring.
Investigators
Duygu Akyol
Principal investigator
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Eligibility Criteria
Inclusion Criteria
- •\>18 years
- •ASA II-III
- •Those with normal renal function
Exclusion Criteria
- •Patients in renal insufficiency
- •Patients with perioperative renal, ureter \& bladder invasion
- •Patients in whom perioperative urine monitoring cannot be performed
- •Patients undergoing HIPEC
- •Patients with missing data
Outcomes
Primary Outcomes
Evaluation of acute kidney injury
Time Frame: Change from preoperative to postoperative day 1(POD1)creatinine values(mg/dl)
Our primary aim was to evaluate the postoperative day(POD1 ) creatinine values(mg/dl)
Secondary Outcomes
- Peroperative fluid amounts(during the operation period)