A study to examine the muscle weakness in intensive care unit patients

Completed

Conditions: Acute and chronic respiratory failure, (2) ICD-10 Condition: Z992||Dependence on renal dialysis, (3) ICD-10 Condition: Z991||Dependence on respirator, (4) ICD-10 Condition: G728||Other specified myopathies, (5) ICD-10 Condition: G628||Other specified polyneuropathies, (6) ICD-10 Condition: J99||Respiratory disorders in diseasesclassified elsewhere, (7) ICD-10 Condition: R652||Severe sepsis, (8) ICD-10 Condition: T794||Traumatic shock,

Brief Summary: ICU acquired weakness is commonly seen in patients who are admitted to the ICU. It is associated with prolonged ICU stay or patients on mechanical ventilation for a longer duration. This lead to poor progression of the patient. A routine assessment for muscle strength is not done in an intensive care unit. Hence the early diagnosis of ICU acquired weakness is often missed and the chances of complications increase. Assessing muscle strength in a regular routine may help to determine the plan of treatment at the beginning if muscle weakness is acquired. This may help to guide further interventions for ICU acquired weakness. Patients will be screened according to the selection criteria. MRC sum score will be performed on these patients. There are six group of muscles that will be tested on both sides. Score will be given from one to five depending upon the grading of the scale. A score less than forty eight will be considered to be cut off for ICU acquired weakness. Muscle strength assessment will be carried out daily till the patient develops weakness or is discharged or is discharged against medical advice. The score will be noted in the data collection sheet. Data will be analyzed at the end of the study period.

Recruitment & Eligibility

Inclusion Criteria

Patients on mechanical ventilation in ICU for more than 48 hours APACHE II score more than 12.

Exclusion Criteria

Diagnosed with pre existing neuromuscular disease Pregnancy Pre existing systemic vascular involvement such as systemic lupus erythematous Patients on inotropes.
Dosage more than 5ml per hour Platelet count below 50,000 per microlitre.

Primary Outcome Measures

Name	Time	Method
Percantage of people diagnosed with ICU acquired weakness based on MRC sum score	First recording when the participant obeys 5 standardized questions which is followed by every day till the patient develops weakness or is discharged or discharged against medical advice or stops following commands or death
Report at what day the patient developes weakness	First recording when the participant obeys 5 standardized questions which is followed by every day till the patient develops weakness or is discharged or discharged against medical advice or stops following commands or death

Secondary Outcome Measures

Name	Time	Method
Number of days on mechanical ventilator, ICU stay	When one of these events occur the patient develops weakness or is discharged or discharged against medical advice or stops following commands or death

Locations (1): Department of Critical Care Medicine
🇮🇳
Udupi, KARNATAKA, India
Department of Critical Care Medicine
🇮🇳Udupi, KARNATAKA, India
Zeal
Principal investigator
9819817448
zeal.chheda@learner.manipal.edu