Testing of respiratory muscle strength in mechanically ventilated patients in intensive care unit.

Not yet recruiting

Conditions: Disorders of diaphragm,

Registration Number: CTRI/2023/10/059176

Lead Sponsor: Sahana S

Brief Summary: Muscle weakness commonly seen in the ICU is known as ICU-acquired weakness (ICU-AW). ICU-AW is detected in 30 to 50% of patients and the incidence is even higher (up to 67%) in critically ill patients with sepsis. The two most common types of muscle weakness associated with ICU stay are peripheral and respiratory muscle weakness. Respiratory muscle weakness is twice as prevalent as limb muscle weakness in ICU patients. Respiratory muscle weakness is associated with a higher risk of weaning failure, a longer duration of ventilator dependence and increases long-term morbidity and mortality. Respiratory muscle weakness is a common cause of weaning failure and is associated with prolonged mechanical ventilation (MV) and prolonged stay in intensive care units. Maximal inspiratory pressure (MIP) is a helpful tool for evaluating inspiratory muscle strength and can be determined by using the end-expiratory occlusion technique. Respiratory muscle strength values can serve as the baseline data for the physiotherapist to develop intervention protocols based on muscle strength that may help improve patient outcomes and decrease health care costs. Therefore, the need arises to measure respiratory muscle strength in ventilated patients. Assessment of Respiratory muscle strength will be done by Maximal Inspiratory Pressure(MIP). This will be done by asking the patient to make inspiratory efforts and hold for 20 seconds. A drop in maximum negative pressure during expiratory hold will be noted. Maximal respiratory pressure is then calculated by the difference between the total PEEP and the maximal negative pressure drop. MIP will be calculated based on the following formula: MIP=TOTAL PEEP â€“ MAXIMAL NEGATIVE PRESSURE. Follow-up for the measurement of respiratory muscle strength will be done till the patient is extubated.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 75

Inclusion Criteria

Mechanically ventilated patients, SIMV or CPAP mode of ventilation 2.
Alert and able to follow simple commands.

Exclusion Criteria

Presence of flail chest or rib fracture 2.
Arrhythmias and acute myocardial infarction 3.
Unconsciousness patient 4.
Neurological damage 5.
Muscular dystrophy 6.
Cognitive/psychiatric/intellectual impairment that impaired to follow commands.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Respiratory muscle strength in ventilated patients.	The respiratory muscle strength will be assessed till the patient is extubated from ventilator support. The outcome will be assessed 4 weeks and 8 weeks apart

Secondary Outcome Measures

Name	Time	Method
Length of stay on the ventilator	Length of stay on a ventilator is predicted till the patient is extubated. The outcome will be assessed after 4 weeks 8 weeks apart.

Trial Locations

Locations (2): Ramaiah Medical College and Hospital
🇮🇳
Bangalore, KARNATAKA, India
Ramaiah Memorial Hospital
🇮🇳
Bangalore, KARNATAKA, India
Ramaiah Medical College and Hospital
🇮🇳Bangalore, KARNATAKA, India
Dr Shaswat Verma
Principal investigator
7338413544
sahanashankar19101999@gmail.com