nderstanding the role of inflammation on the occurrence of cognitive impairment (memory decline) related to cancer chemotherapy in lymphoma patients
- Conditions
- Health Condition 1: C858- Other specified types of non-Hodgkin lymphoma
- Registration Number
- CTRI/2020/09/027732
- Lead Sponsor
- Jamia Hamdard
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 83
Patient must have histologically and cytologically confirmed lymphoma; patient receiving chemotherapy for the treatment of lymphoma; capable of giving informed consent; willing to participate in the study.
Patient below 18 years of age, history of cognitive impairment and Alzheimerââ?¬•s disease; history of depression; history of head injury; patient with history of any type of cancer; any cancer patient with brain involvement; ongoing psychotropic medications; history of schizophrenia or any other neuropsychiatric disorders; habit of any substance of abuse; using any concurrent medication for any neuropsychiatric disorder; using anti-inflammatory drugs; incompetent for interview; not willing to participate and give consent for the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Possible correlation of different inflammatory mediators with chemotherapy-related cognitive impairment <br/ ><br>Timepoint: a)Before 1st cycle of chemotherapy (at baseline) <br/ ><br>b)Before 4th cycle of chemotherapy (T2) <br/ ><br>c)After 6th cycle of chemotherapy (T3) <br/ ><br>
- Secondary Outcome Measures
Name Time Method Change in the quality of life of lymphoma patients after receiving chemotherapyTimepoint: At the end of 6th cycle of chemotherapy;Dysregulation of serum levels of peripheral inflammatory markers after cycles of chemotherapyTimepoint: After six cycles of chemotherapy;Probable occurrence of cognitive impairment after receiving consecutive cycles of chemotherapyTimepoint: AFter 6 cycles of chemotherapy;Probable occurrence of depression after receiving consecutive cycles of chemotherapyTimepoint: After 6 cycles of chemotherapy