eutrophil function in type 2 diabetes and infectio
Not Applicable
- Conditions
- Health Condition 1: A419- Sepsis, unspecified organismHealth Condition 2: E116- Type 2 diabetes mellitus with other specified complications
- Registration Number
- CTRI/2020/12/029936
- Lead Sponsor
- Manipal Academy of Higher Education
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Healthy Non-diabetic control – Age 40 – 65 years, Fasting glucose less than 100mg/dl
Non-diabetic subjects with Sepsis – Non Diabetic and bacterial sepsis
Type 2 Diabetes – HbA1c grater than 8.0%
Type 2 Diabetes with sepsis - HbA1c greater than 8.0% and bacterial sepsis
Exclusion Criteria
Iatrogenic or endogenous Cushing’s syndrome, Usage of glucocorticoids, Non-bacterial sepsis, Immunosuppression and autoimmune diseases
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The present proposal addresses underlying mechanisms due to cross talk between granulopoiesis and metabolism in T2D conditions. Evolving knowledge of host-pathogen interaction in T2D might provide innovative, preventive and therapeutic approaches for infectious disease and inflammatory disorders. Our study will identify novel cellular and molecular mechanisms regulating neutrophil (dys)function in T2D.Timepoint: 3 years
- Secondary Outcome Measures
Name Time Method Findings possess translational potential and will facilitate to develop diagnostic markers.Timepoint: 3 years