Protein Requirements for Active Adolescent Males (IAAO-AM)

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Amino Acid Intake

• Registration Number: NCT02859181
• Lead Sponsor: University of Toronto

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in adolescent, males using the IAAO technique in the presence of a variable intensity exercise stimulus.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-06-10
• Study First Submitted QC: 2016-08-03
• Study First Posted: 2016-08-08
• Study Start: 2016-10
• Primary Completion: 2017-11-15
• Study Completion: 2018-04-30
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-28
• Last Update Posted: 2019-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 7

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Active, Adolescent males	Amino Acid Intake	Subjects will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d

Primary Outcome Measures

Name	Time	Method
13CO2 ([13]Carbon Dioxide) Excretion (µmol/kg/h)	4 hours per study day	Each trial day will assess a different protein intake with 13CO2 excretion defining the level of protein adequacy. Each trial day will be separated by \~1wk washout with all trial being completed in approximately 3 months.

Secondary Outcome Measures

Name	Time	Method
[13C]Phenylalanine Oxidation (µmol/kg/h)	4 hours per study day	Each trial day will assess a different protein intake with 13CO2 excretion defining the level phenylalanine oxidation being used as a secondary marker of protein adequacy. Each trial day will be separated by \~1wk washout with all trial being completed in approximately 3 months.

Trial Locations

Locations (1)

Goldring Centre for High Performance Sport; 🇨🇦 Toronto, Ontario, Canada