Protein Requirements In Active Populations

Not Applicable

Completed

• Conditions: Healthy; Increased Metabolic Requirement
• Interventions: Dietary Supplement: Amino Acid Intake

• Registration Number: NCT02478814
• Lead Sponsor: University of Toronto

Brief Summary

Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.

The purpose of this study is to measure the protein requirement in active, young adult males using the IAAO technique in the presence of a variable intensity exercise stimulus.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-06-18
• Study First Submitted QC: 2015-06-18
• Study First Posted: 2015-06-23
• Primary Completion: 2016-06
• Study Completion: 2017-12
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-28
• Last Update Posted: 2019-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 7

Inclusion Criteria

• Healthy, active, young adult males who regularly participate in moderate-vigorous activity 5x per week, for a minimum of 1 hour
• A minimum score of 10 on the Beep Test (a measure of aerobic fitness)

Exclusion Criteria

• Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Active, Young Adult Males	Amino Acid Intake	Subjects will receive different levels of amino acid intakes varying from 0.2 to 2.6 g/kg/day.

Primary Outcome Measures

Name	Time	Method
13CO2 (carbon dioxide) excretion (μmol/kg/h)	4 hours / study day

Secondary Outcome Measures

Name	Time	Method
13C-Phenylalanine Oxidation (μmol/kg/h)	4 hours / study day