Correlation of functional tumour volume on PETCT of primary lung cancer with histopathological tumour size.
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients with histological confirmation of diagnosis of Non small cell lung cancer (NSCLC)
- Registration Number
- CTRI/2015/07/005967
- Lead Sponsor
- Tata Memorial Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 25
Inclusion Criteria
1)Treatment cases with histological confirmation of diagnosis of Non small cell lung cancer (NSCLC).
2)Non metastatic early- stage operable lung cancer size <5cm (T1-T3/N0) on pretreatment PETCT staging.
3)PET-CT scan performed within 8 wks before surgical resection of tumour.
4)Surgical resection either a lobectomy or pneumenectomy
Exclusion Criteria
1)Patients who received chemotherapy prior to surgery.
2)Positive margins post resection as on histopathology report.
3)PETCT performed 8 weeks prior to resection
4)Previously treated cases of cancer.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To determine the cut-off standardized uptake value (SUV) on 18F fluoro-2-deoxy-glucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) images that correlates best with pathologic gross tumor volume (GTVpath) for nonâ??small-cell lung cancer (NSCLC) by various (semi) automated delineation methods, to compare CT based visual assessment with pathology.Timepoint: NI
- Secondary Outcome Measures
Name Time Method 1 compare differences in tumor volume as delineated by various semiautomated methods and corresponding data obtained on pathological specimen and to quantify the magnitude of difference <br/ ><br>2 Determine interobserver variability between observers in auto-contourâ??based delineation in the delineation of the GTV and manual PET-CTâ??based delineation in patients with untreated NSCLC. <br/ ><br>3.Validation of the obtained results of one best fit method on subsequent 15 patients in validation group <br/ ><br>Timepoint: NI