Systemic, Intrapulmonary and Pleural Inflammatory Reaction in Patients Undergoing Thoracic Surgery

Completed

• Conditions: Lung Neoplasms

• Registration Number: NCT00558350
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

Inflammatory reaction in different compartments of the body may have a negative effect on outcome. This study assesses the inflammatory reaction systemically, intrapulmonary and intrapleural by measuring different cytokines. Patients with lung cancer undergoing lobectomy or segmentectomy are included in the study. Hypothesis: The inflammatory reaction in the pleural space is high compared to the systemic and intrapulmonary ones.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-04
• Study First Submitted: 2007-11-13
• Study First Submitted QC: 2007-11-13
• Study First Posted: 2007-11-14
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Status Verified: 2012-03
• Last Update Submitted: 2012-03-14
• Last Update Posted: 2012-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• elective lobectomy
• elective segmentectomy
• 20-90 years
• informed consent given

Exclusion Criteria

• emergency operations
• pneumonectomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cytokine levels in blood, bronchial lavage fluid and pleural fluid	2 years
Correlation between cytokine levels and pulmonary morbidity	2 years

Secondary Outcome Measures

Name	Time	Method
Comparison of this collective with transthoracic esophagectomies and evaluation of the inflammatory reactions (esophageal collective registered:NCT00512265)	4 years

Trial Locations

Locations (1)

University Hospital Basel; 🇨🇭 Basel, Switzerland