Comparative Study Between Endocan and Copeptin Serum Levels in Preterm Neonates With Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Serum endocan level for prediction of severity of respiratory distress syndrome
研究概览
简要总结
This work aims to investigate and compare the levels of serum endocan and serum copeptin on the first day of life and correlate their levels to the severity of respiratory distress in preterm neonates suffering from respiratory distress syndrome.
详细描述
Preterm birth continues to be one of the significant challenges in perinatal medicine because of its high incidence of morbidities and mortalities. Its burden on the infant, the family, healthcare systems, and society is enormous.
Endocan is implicated in the recruitment of circulating lymphocytes to inflammatory sites and leukocyte adhesion and activation. Endocan also inhibits leukocyte-endothelial cell adhesion and reduces the excessive leukocyte recruitment into the lungs.
Copeptin, also known as the arginine vasopressin (AVP) associated glycopeptides. AVP is a vasoactive neurohypophysial hormone. It is one of the primary hormones of the hypothalamic-pituitary-adrenal axis, and its primary function is to regulate water and maintain electrolyte homeostasis. The primary stimulus for AVP release is hyperosmolarity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 28 Weeks 至 36 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prematurity.
- •Gestational age between 28 and 36 weeks.
- •Suffering from respiratory distress syndrome.
排除标准
- •Intrauterine growth restriction (IUGR).
- •Hypoxic ischemic encephalopathy.
- •Multiple congenital anomalies.
- •Chromosomal abnormalities.
- •Preterm less than 28 weeks.
- •Neonates with a maternal history of chorioamnionitis (early sepsis).
- •Infant of diabetic mother.
- •Prelabor rupture of membranes (PROM)> 2 hours.
结局指标
主要结局
Serum endocan level for prediction of severity of respiratory distress syndrome
时间窗: First day of life
Serum endocan level for prediction of severity of respiratory distress syndrome (RDS) will be recorded.
次要结局
- Serum copeptin level for prediction of severity of respiratory distress syndrome(5th day of life)
- Serum endocan level for prediction of mortality(First day of life)
- Serum copeptin level for prediction of mortality(5th day of life)
研究者
Asmaa Mahmoud Abdel Hamid Elmesiry
Lecturer of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University