Clinical Pre-screening Protocol for Ovarian Cancer
Active, not recruiting
- Conditions
- Ovarian Cancer
- Interventions
- Device: Drug Response Predictor® (DRP)
- Registration Number
- NCT03877796
- Lead Sponsor
- Allarity Therapeutics
- Brief Summary
The pre-screening study is established to pre-screen tumor samples from ovarian cancer patients to identify if they, at a later stage of their disease, will benefit from treatment with any investigational cancer drugs available to Oncology Venture, when these drugs are approved for future clinical studies by local authorities.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
- Patients with histological confirmed epithelia ovarian cancer
- Relapse after 2 or more chemotherapies for ovarian cancer
- FFPE tumor tissue available
Exclusion Criteria
- Other primary malignancy within the last 5 years prior to enrolment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Ovarian cancer patients Drug Response Predictor® (DRP) with formalin-fixed paraffin-embedded (FFPE) tumor tissue available
- Primary Outcome Measures
Name Time Method Identification of ovarian cancer patients with high likelihood of being sensitive to investigational cancer drug up to 2 years based on FFPE ovarian cancer tissue
- Secondary Outcome Measures
Name Time Method Retrospective analysis of whether or not the DRP method can predict and confirm the obtained sensitivity to the prior drugs used in the treatment of ovarian cancer up to 2 years
Trial Locations
- Locations (5)
Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital
🇬🇧London, United Kingdom
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
OU Health Stephenson Cancer Center
🇺🇸Oklahoma City, Oklahoma, United States
Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, Scotland, United Kingdom
Swedish Center for Research and Innovation
🇺🇸Seattle, Washington, United States