Japanese study for usefulness of vitamin E in reducing aromatase inhibitor-associated joint symptoms
Phase 2
- Conditions
- Breast cancer
- Registration Number
- JPRN-UMIN000004416
- Lead Sponsor
- Cancer Institute Hospital Breast Center
- Brief Summary
The osteoarthropathy scores significantly decreased after vitamin E administration (p=0.0243), while serum-estradiol concentrations did not change. The serum-estradiol concentrations before vitamin E administration in the group sensitive to the vitamin E efficacy were significantly lower, as compared with those in the insensitive group (p=0.0005). J Cancer 6(4): 367-376. 2015
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who are suffering bone or joint disease, such as rheumatoid arthritis, osteoarthritis deformans, frozen shoulder syndrome, severe osteoporosis etc. Previous history of neurological disorder Recurrent breast cancer cases Vitamin E users as supplement Patients who are taking a anticoagulant or are expected surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum concentration of estrogen
- Secondary Outcome Measures
Name Time Method Efficacy for joint symptom, adverse event, serum concentration of vitamin E and IL-6