The Influence of Warm Bupivacaine on Supraclavicular Plexus Block Characteristics
- Conditions
- Surgery to the Distal One Third of the Upper Limb
- Interventions
- Registration Number
- NCT03265886
- Lead Sponsor
- Mansoura University
- Brief Summary
Despite PH adjustment of local anesthetic solution improves the quality of the block in all respects with special advantage of early onset of sensory and motor block, adequate level of analgesia, and prolongation of duration of block, the effect of warmed bupivacaine should have the same effect which have not been evaluated on supraclavicular plexus block for upper limb surgery.
The warmed bupivacaine used in supraclavicular plexus block may reduce sensory and motor block onset and prolong the duration of analgesia when compared to bupivacaine at operating room temperature.
- Detailed Description
The aim of this study is to compare the effect of warm bupivacaine 0.5% at 37◦C versus bupivacaine 0.5% at operating room temperature at 23◦C on ultrasound-guided supraclavicular plexus block characteristics as regard sensory block onset time, motor block onset time, duration of sensory and motor block , effective duration of analgesia, total analgesics requirement, complications and side effects.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- American Society of Anesthesiologists physical class I or II
- Patient refusal.
- Pregnancy
- Neuromuscular diseases (as myopathies, myasthenia gravies...)
- Hematological diseases
- Bleeding disorders
- Coagulation abnormality.
- Psychiatric diseases.
- Local skin infection
- Sepsis at site of the block.
- Known intolerance to the study drugs.
- Body Mass Index > 40 Kg/m2.
- Bilateral upper limb injury to be performed at the same procedure.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bupivacaine at operating room temperature (23°c) Bupivacaine at operating room temperature (23°c) Bupivacaine at temperature of 23°C will be administered Warm bupivacaine at (37°c) Warm bupivacaine at (37°c) Warmed bupivacaine at body temperature will be administered
- Primary Outcome Measures
Name Time Method Time to onset of sensory block for 30 min following injection defined as the time interval between the end of local anesthetic injection and the loss of sensation to pinprick (sensory score = 1)
- Secondary Outcome Measures
Name Time Method Heart rate For 3 hours after the injection of local anesthetic Duration of sensory block For 24 hours after the injection of local anesthetic defined as the interval between end of injection and complete end of sensory block (score=2)
Satisfaction Score for 48 hrs after the injection of local anesthetic Using score including 5-Excellent, 4-Very Good, 3-Good, 2-Fair, and 1-Poor
Blood pressure For 3 hours after the injection of local anesthetic The severity of postoperative pain For 24 hours after the injection of local anesthetic will be measured and recorded by using a 100-cm visual analog scale (VAS) for pain, where 0 is equal to no pain and 100 indicates the worst possible pain.
Time to onset of motor block For 3 hours after the injection of local anesthetic defined as time interval between the end of local anesthetic injection and (motor score = 1) in the distributions of all 4 peripheral nerves.
oxygen saturation in the peripheral blood For 3 hours after the injection of local anesthetic Time for first analgesic request For 24 hours after the injection of local anesthetic Time to the first receiving of rescue analgesic from the time of blockade
Duration of motor block For 24 hours after the injection of local anesthetic defined as the interval between end of injection and complete recovery of normal motor function (score=0), respectively.
Total analgesics received for 24 hrs after the injection of local anesthetic Cumulative use of rescue analgesics after performing the blockade
Trial Locations
- Locations (1)
Mansoura University, Faculty of Medicine
🇪🇬Mansourah, DK, Egypt