Effects of Positive End-Expiratory Pressure on Biventricular Function During One-Lung Ventilation

Not Applicable

Completed

• Conditions: Lung Cancer
• Interventions: Procedure: PEEP

• Registration Number: NCT02483806
• Lead Sponsor: Yonsei University

Brief Summary

One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Wang et al measured intrapulmonary shunt by transesophageal echocardiography. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Applying PEEP(Positive End-expiratory Pressure) at dependent lung and CPAP at non-dependent lung can mitigate the hypoxemia. Above all, PEEP can be easily applicable. However, there are controversial studies whether it is supportive or not. In this prospective, cross-over study, the investigators are planning to investigate the effects of PEEP on intrapulmonary shunt, oxygenation and cardiac function as well.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-06-19
• Study First Submitted QC: 2015-06-24
• Study Start: 2015-06-29
• Study First Posted: 2015-06-29
• Primary Completion: 2016-05-25
• Study Completion: 2016-05-25
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-26
• Last Update Posted: 2017-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• scheduled for VATS lobectomy
• 40 ≤ age ≤ 80
• American Society of Anaesthesiologists(ASA) physical status classification I~III

Read More

Exclusion Criteria

• American Society of Anaesthesiologists(ASA) physical status classification IV
• NYHA class III~IV
• Severe obstructive lung disease and/or restrictive lung disease patients
• those with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
• arrhythmia
• esophageal varix
• pregnant women

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
PEEP 0 cmH2O	PEEP	PEEP 0 cmH2O (zero end expiratory pressure, ZEEP)
PEEP 5 cmH2O	PEEP	-
EEP 10 cmH2O	PEEP	-

Primary Outcome Measures

Name	Time	Method
the effect of differential PEEP (0, 5, 10 cmH2O) by PaO2(P/F ratio)	20 minutes after each PEEP apply
Cardiac function	20 minutes after each PEEP apply	cardiac function : Tei index

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of