Effects of Positive End-Expiratory Pressure on Biventricular Function During One-Lung Ventilation: a Randomized Crossover Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- the effect of differential PEEP (0, 5, 10 cmH2O) by PaO2(P/F ratio)
研究概览
简要总结
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Wang et al measured intrapulmonary shunt by transesophageal echocardiography. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Applying PEEP(Positive End-expiratory Pressure) at dependent lung and CPAP at non-dependent lung can mitigate the hypoxemia. Above all, PEEP can be easily applicable. However, there are controversial studies whether it is supportive or not. In this prospective, cross-over study, the investigators are planning to investigate the effects of PEEP on intrapulmonary shunt, oxygenation and cardiac function as well.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for VATS lobectomy
- •40 ≤ age ≤ 80
- •American Society of Anaesthesiologists(ASA) physical status classification I~III
排除标准
- •American Society of Anaesthesiologists(ASA) physical status classification IV
- •NYHA class III~IV
- •Severe obstructive lung disease and/or restrictive lung disease patients
- •those with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
- •arrhythmia
- •esophageal varix
- •pregnant women
研究组 & 干预措施
PEEP 0 cmH2O
PEEP 0 cmH2O (zero end expiratory pressure, ZEEP)
干预措施: PEEP (Procedure)
PEEP 5 cmH2O
干预措施: PEEP (Procedure)
EEP 10 cmH2O
干预措施: PEEP (Procedure)
结局指标
主要结局
the effect of differential PEEP (0, 5, 10 cmH2O) by PaO2(P/F ratio)
时间窗: 20 minutes after each PEEP apply
Cardiac function
时间窗: 20 minutes after each PEEP apply
cardiac function : Tei index
次要结局
未报告次要终点