Effect of Iloprost on Pulmonary Oxygenation in Patients With Low Diffusing Capacity During One-lung Ventilation

Not Applicable

Completed

• Conditions: Lung Cancer
• Interventions: Drug: normal saline; Drug: iloprost

• Registration Number: NCT02784899
• Lead Sponsor: Yonsei University

Brief Summary

One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, investigators are planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc).

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10-08
• Study First Submitted: 2016-05-16
• Study First Submitted QC: 2016-05-24
• Study First Posted: 2016-05-27
• Primary Completion: 2017-06-30
• Study Completion: 2017-06-30
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-19
• Last Update Posted: 2018-06-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• scheduled for Video-assisted thoracoscopic surgery (VATS) lobectomy
• 40 < age < 80
• American Society of Anaesthesiologists (ASA) physical status classification I~III
• diffusing capacity (DLCO) <75% at pre op. pulmonary function test

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Exclusion Criteria

• American Society of Anaesthesiologists (ASA) physical status classification IV
• New York Heart Association (NYHA) class III~IV
• Severe obstructive lung disease and/or restrictive lung disease patients
• patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
• arrhythmia
• pregnant women
• disease that can influence the DLCO result (anemia, pulmonary vascular disease)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	normal saline	normal saline inhalation group
iloprost group	iloprost	iloprost inhalation group

Primary Outcome Measures

Name	Time	Method
PaO2(partial pressure of arterial oxygen) ratio	40 minutes after iloprost inhalation
incidence of intrapulmonary shunt	40 minutes after iloprost inhalation

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of