Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation
Overview
- Phase
- Not Applicable
- Intervention
- normal saline inhalation
- Conditions
- Lung Cancer (Including Metastatic Cancer)
- Sponsor
- Yonsei University
- Enrollment
- 78
- Locations
- 1
- Primary Endpoint
- Result of arterial blood gas analysis : partial pressure of oxygen(PaO2)
- Status
- Completed
- Last Updated
- 5 months ago
Overview
Brief Summary
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, the investigator is planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •scheduled for VATS lobectomy
- •40 \< age \< 80
- •American Society of Anaesthesiologists(ASA) physical status classification I\~III
- •BMI \> 30 kg /m2
Exclusion Criteria
- •American Society of Anaesthesiologists(ASA) physical status classification IV or more
- •NYHA class III\~IV
- •Severe obstructive lung disease and/or restrictive lung disease patients
- •patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
- •pregnant women
- •pulmonary edema or pulmonary arterial hypertension
- •cerebrovascular disease
- •unstable angina or myocardial infarction within 6 months
- •patients with allergic reaction at iloprost
Arms & Interventions
placebo
normal saline inhalation group
Intervention: normal saline inhalation
iloprost group
iloprost inhalation group
Intervention: iloprost inhalation
Outcomes
Primary Outcomes
Result of arterial blood gas analysis : partial pressure of oxygen(PaO2)
Time Frame: 20 minutes after iloprost inhalation (T2)
Result of arterial blood gas analysis : partial pressure of oxygen in the arterial blood(PaO2)/Fraction of inspired oxygen(FiO2) ratio (P/F ratio)
Time Frame: 20 minutes after iloprost inhalation (T2)
Result of arterial blood gas analysis : Oxygen saturation in arterial blood(SaO2)
Time Frame: 20 minutes after iloprost inhalation (T2)
Secondary Outcomes
- deadspace(20 minutes after iloprost inhalation (T2))
- intrapulmonary shunt(20 minutes after iloprost inhalation (T2))