Effects of Iloprost on Pulmonary Oxygenation in Obese Patients During One-lung Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Result of arterial blood gas analysis : partial pressure of oxygen(PaO2)
研究概览
简要总结
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, the investigator is planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc) in obese patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for VATS lobectomy
- •40 < age < 80
- •American Society of Anaesthesiologists(ASA) physical status classification I~III
- •BMI > 30 kg /m2
排除标准
- •American Society of Anaesthesiologists(ASA) physical status classification IV or more
- •NYHA class III~IV
- •Severe obstructive lung disease and/or restrictive lung disease patients
- •patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure)
- •pregnant women
- •pulmonary edema or pulmonary arterial hypertension
- •cerebrovascular disease
- •unstable angina or myocardial infarction within 6 months
- •patients with allergic reaction at iloprost
研究组 & 干预措施
placebo
normal saline inhalation group
干预措施: normal saline inhalation (Drug)
iloprost group
iloprost inhalation group
干预措施: iloprost inhalation (Drug)
结局指标
主要结局
Result of arterial blood gas analysis : partial pressure of oxygen(PaO2)
时间窗: 20 minutes after iloprost inhalation (T2)
Result of arterial blood gas analysis : partial pressure of oxygen in the arterial blood(PaO2)/Fraction of inspired oxygen(FiO2) ratio (P/F ratio)
时间窗: 20 minutes after iloprost inhalation (T2)
Result of arterial blood gas analysis : Oxygen saturation in arterial blood(SaO2)
时间窗: 20 minutes after iloprost inhalation (T2)
次要结局
- deadspace(20 minutes after iloprost inhalation (T2))
- intrapulmonary shunt(20 minutes after iloprost inhalation (T2))